The 26-year-old Liverpool star finished first with club-mate Senegalese Sadio Mane and Arsenal and Gabon striker Pierre-Emerick Aubameyang the other finalists.
It was an identical outcome to last year when Salah became only the second Egyptian after 1983 winner Mahmoud al Khatib to be voted the best footballer in Africa.
Having defended his Player of the Year title, his next goal will be to match the four straight wins in the competition by former Manchester City and Ivory Coast star Yaya Toure.
The other male awards went to France-born Morocco coach Herve Renard, the Mauritania national team, and Moroccan Achraf Hakimi in the youth category.
South African Chrestinah Kgatlana was voted Women’s Player of the Year and South Africa coach Desiree Ellis and the Nigeria national team were the other female winners.
The Goal of the Year award also went to Kgatlana.